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The serum-growth hormone response to exercise is greater and occurs earlier in juvenile diabetics than in nondiabetics. A simple exercise test has been devised which unequivocally reveals the growth hormone hypersecretion of juvenile diabetics. Using this procedure we have shown that after a period of exceedingly strict metabolic control of the diabetes, complete normalization of growth hormone secretion is attained. It is concluded that the abnormalities in serum growth hormone found in juvenile diabetics are of a metabolic origin.

Normalization of growth hormone hyperresponse to exercise in juvenile diabetics after “normalization” of blood sugar