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The term "rhinovirus" (1-3) is now used to designate a group of immunologically distinct respiratory viruses, possessing many properties of enteroviruses but differing by lability in acid media (4-6) and almost exclusive multiplication in the nasopharynx. The first agents isolated that fit this description were the JH and 2060 strains of ECHO28 isolated by Price (7) and Pelon, Mogabgab, Phillips, and Pierce (8) in 1956 and classified by Pelon (9). Modifications in tissue culture technique for isolating these and similar agents, i.e., incubation on a rotating drum and reduction in pH to 7.0 to 7.3, were introduced by Pelon and Mogabgab (10) and extended by Tyrrell and associates (4) and Tyrrell and Parsons (5) to include an incubation temperature of 330 C and use of human tissues. Subsequently, many rhinoviruses, reported under a variety of names, have been isolated in association with mild respiratory illnesses (11-16). Some of the strains grow only in tissues of human origin (H strains) and some as well in monkey kidney tissue culture (M strains) (3, 5). It has been estimated that rhinoviruses account for 35 to 40%o of the common colds in adults (17). Tyrrell, Bynoe, and co-workers (4, 18-20) and Jackson, Dowling, and Mogabgab (21), who have administered rhinoviruses to volunteers, have demonstrated that the viruses can infect and produce common colds and that protection is associated with the presence of specific neutralizing antibody in the serum. After the isolation of other strains of rhinovirus, NIH 353, 1734, and 11757, by

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Studies with Rhinoviruses in Volunteers: Production of Illness, Effect of Naturally Acquired Antibody, and Demonstration of a Protective Effect Not Associated with Serum Antibody*