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The respiratory function of the blood depends on a series of reversible reactions of oxygen and carbon dioxide with blood. The optimal performance of this function requires that the rate of these reactions be such as to permit them to approach completion within the time the blood spends in the vessels of gas exchange. In the case of carbon dioxide, experiments by Roughton (1) and more recently by Forster (2), using different methods, have suggested that the reactions involved may be slow enough to limit the excretion of CO2 in the lung. Most of the work in this field has been performed in vitro, and because of the difficulty in carrying over the information obtained to living systems, we have devised a technique by which some aspects of the reactions leading to CO2 liberation in the lung can be studied in living animals.

THE RATE OF INTRAPULMONARY BLOOD GAS EXCHANGE IN LIVING ANIMALS*