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Particles of fat large enough to scatter light and cause turbidity appear in plasma after a fatty meal. Gage and Fish described the appearance of these particles ("chylomicrons") in the darkfield microscope -and appreciated that they could be heterogeneous (1). They observed small particles circulating during early and late stages of fat absorption, and a predominance of larger particles during peak lipemia. Further attempts, however, to classify these particles by using darkfield microscopy have yielded inconsistent results (2, 3). Centrifugation of lipemic plasma also has not proved useful for sharply fractionating fat particles. There appears to be an array of fat particles of different sizes and flotation rates that can be spun up by varying the force and duration of centrifugation in a saline (d < 1.006) or plasma medium (4). Arbitrary separations can be made based on the choice of centrifugal conditions (5, 6). Properties other than size and density characterize these fat particles. In lymph and plasma, they are negatively charged and move toward the anode on free electrophoresis (7). With this technique, Swahn found that in a variety of lipemic samples, turbidity associated with larger fat particles migrated with alpha2 globulin while smallparticle turbidity migrated with beta globulin (8). Carlson and Olhagen, using starch column electrophoresis, observed two turbid peaks in plasma from a patient with essential hyperlipemia (9). In the present study, zone electrophoresis on starch granules has been used to separate two distinct groups of fat particles appearing in plasma during alimentary lipemia. This separation also

HETEROGENEITY OF FAT PARTICLES IN PLASMA DURING ALIMENTARY LIPEMIA*