English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Progesterone 1 is a metabolic precursor common to cortisol and corticosterone biosynthesis in the adrenal cortex. However, incubation of radioactive progesterone with bovine adrenal homogenates (1) and human adrenal slices (2, 3) yields corticosterone with a specific activity greater than that of cortisol, even though the amount of cortisol produced is greater. Although hypotheses involving enzyme kinetics have been suggested to explain these results, other pathways of cortisol biosynthesis may exist that do not involve progesterone. The pathway from progesterone to cortisol is believed to be via 17-hydroxyprogesterone -* 11deoxycortisol -> cortisol (4). Progesterone is derived from A5-pregnenolone upon oxidation of the 3,8-hydroxyl group and a shift of the double bond. Hydroxylation of A5-pregnenolone to 17a-hydroxyA5-pregnenolone is considered the first step in adrenal androgen biosynthesis (5). Conversion of 17-hydroxy-A'5-pregnonolone to 17a-hydroxy-progesterone by oxidation of the 3/3-hydroxyl group and a shift of the double bond appeared to be a reasonable alternative possibility for cortisol biosynthesis. Indeed, Weliky and Engel (6) reported that 17-hydroxy-_A5-pregnenolone is metabolized to cortisol by sheep adrenal homogenates and by slices of a human adrenal tumor, and the present authors in preliminary reports have shown the conversion of 1 7a-hydroxy-A5-pregnenolone-7-H3

CONVERSION OF 17-HYDROXY-PREGNENOLONE TO CORTISOL BY NORMAL AND HYPERPLASTIC HUMAN ADRENAL SLICES*