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In contrast to many other cell types in which a variety of metabolic pathways may contribute to energy production, the human erythrocyte derives its energy almost exclusively from the breakdown of glucose to lactate via the glycolytic sequence. Lactate can arise also from glucose by an alternate route, namely the hexose monophosphate shunt and the pentose cycle, but this latter pathway is relatively inoperative in the erythrocyte under normal conditions, owing to the unexplained preferential conversion of glucose-6-phosphate to fructose-6-phosphate, rather than to 6-phosphogluconate. The red cell, therefore, offers a unique opportunity to correlate physiological function, or malfunction, with enzymatic activity, since the number of metabolic pathways, fortunately, is somewhat restricted. In the present investigation a detailed study has been undertaken to define the optimal conditions for the conversion of glucose to lactate in the intact erythrocyte and in hemolysates. In addition, levels of the individual glycolytic enzymes have been determined and this information has been used to discuss regulatory mechanisms of glycolvsis in the ervthrocyte.

ERYTHROCYTE METABOLISM. V. LEVELS OF GLYCOLYTIC ENZYMES AND REGULATION OF GLYCOLYSIS*