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Angiotensin II has been shown to increase the excretion (1) and secretion (2) of aldosterone by normal human subjects, and the secretion of aldosterone by hypophysectomized, nephrectomized dogs (3-5). In the latter preparation (3), renin, which leads to the liberation of angiotensin in the circulation (6), has been shown to stimulate aldosterone secretion. The present studies were done to determine whether angiotensin and renin can act directly on the adrenal cortex. It will be shown that angiotensin II, like ACTH, does have such a direct effect, and renin does not. The effect of various precursors on the biosynthesis of aldosterone was determined and compared with their effect in the presence of ACTHand angiotensin II. In this way, we have sought to identify and compare the loci of action of ACTHand angiotensin II in the biosynthesis of aldosterone.

THE EFFECT OF ACTH, RENIN, ANGIOTENSIN II, AND VARIOUS PRECURSORS ON BIOSYNTHESIS OF ALDOSTERONE BY ADRENAL SLICES