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In studies in animals it has been shown (1) that the chain length of a fatty acid is related to the extent of its absorption; i.e., the greater the molecular weight, the less the degree of absorption. It has been our purpose to find whether this relationship is true also in patients with steator-rhea. We have studied the absorption of various fatty acids, fed as triglycerides, in patients who have disturbed fat absorption due to celiac disease, cystic fibrosis of the pancreas, and ileectomy. The steatorrhea in each of these categories is based on distinctly different defects. In celiac disease the poor fat absorption is caused by. dysfunction of the mucosal cells (2), but in cystic fibrosis the steator-rhea reflects diminished lipolysis due to deficiency of pancreatic lipase. In the third instance-operative shortening of the intestine-there is obviously a reduction of mucosal surface available for absorption. Also it has been our purpose to determine whether the absorption of a given fatty acid is influenced by simultaneously feeding other fatty acids. This may have therapeutic implications in that it could afford a guide to the choice of dietary fats for patients with steatorrhea. Various experimental designs have been used in the past for studying the process of fat absorption. Some investigations, in both animal experi-TABLE I Composition offat mixtures used in the different experiments Fatty acids* (%)t Fat and fat mixtures

DIFFERENCES IN ABSORPTION OF THE VARIOUS FATTY ACIDS STUDIED IN CHILDREN WITH STEATORRHEA