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There is now abundant evidence that both cortisol and corticosterone are bound in plasma to a protein with high affinity and low capacity (probably an a-globulin termed transcortin) as well as to albumin (1-10). It has also been shown that either the concentrations of transcortin or its affinity for cortisol is increased in pregnancy and after estrogen treatment (4, 10), although one group (10) has not found increased binding of tracer amounts of cortisol in pregnancy. Preliminary studies by Mills, Chen and Bartter (7, 8) indicated that aldosterone is bound to proteins other than albumin to a much lesser extent than is cortisol. Sandberg, Slaunwhite and Carter (9) reported an appreciable binding of aldosterone in diluted plasma dialyzed against albumin at 40 C. The aldosterone was readily displaced from the binding protein by the addition of cortisol, while cortisol binding under similar conditions was not significantly reduced by the addition of physiological amounts of aldosterone (9). During the preparation of this manuscript Daughaday, Holloszy and Mariz (10) reported that at 370 C they could not demonstrate any binding of aldosterone to proteins other than albumin in the plasma of normal women or in that of pregnant subjects and women treated with estrogen, but they found appreciable binding of aldosterone to such a protein in normal plasma at 40 C. The present paper gives detailed data on the binding of aldosterone in normal plasma, obtained by a microdialysis technique with 7-H3aldosterone of high specific activity (20 fsc per pg). Plasma from pregnant subjects and from

THE BINDING OF ALDOSTERONE TO PLASMA PROTEINS IN NORMAL, PREGNANT, AND STEROID-TREATED WOMEN*