English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

The pathogenesis of the febrile response that follows the intravenous injection of bacterial endotoxin has been the subject of extensive investigations. In the course of these studies it became evident that blood serum contains factors which, when interacted in vitro with endotoxin, may either enhance or inactivate the fever-producing effects. LeQuire demonstrated that a brief period of interaction between serum and endotoxin results in augmentation of pyrogenicity (3). Others have confirmed this observation and have, in addition, defined some of the conditions necessary for demonstrating the pyrogen-enhancing effect of serum (4-8). In seeking to explain the termination of endotoxin fever, Hegemann postulated that this was effected by components of serum capable of detoxifying endotoxin. He demonstrated the presence of such agents in serum by incubating endotoxin and serum for prolonged periods at physiological temperature (9-12). However, these experiments did not provide evidence that this effect of serum was operative in the termination of endotoxin fever. The observations of LeQuire and of Hegemann were confirmed by Cluff and Bennett (8), who clearly distinguished the two effects of serum by demonstrating that pyrogen augmentation was not dependent upon the time or temperature of incuba-

INACTIVATION OF ENDOTOXIN BY A HUMORAL COMPONENT. VII. ENZYMATIC DEGRADATION OF ENDOTOXIN BY BLOOD PLASMA*