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The study of the disappearance of the radioactivity in plasma after the injection of labeled aldosterone should elucidate the transport and metabolism of this steroid in man. In particular this would allow the calculation of the turnover rate in various clinical conditions. This value, together with a concomitant determination of the secretion rate estimated from the specific activity of a urinary metabolite, would enable the mean blood concentration of aldosterone to be calculated. This is particularly important at the present time, as no practical direct method has yet been reported for the analysis of aldosterone in peripheral blood. After the administration of 16-H13-aldosterone to one normal subject, the labeled hormone had a half-life in plasma of 20 minutes, as calculated from the change in concentration of radioactivity measured specifically as aldosterone between 2 and 3 hours after the injection (1). This indicated that the rate of metabolism of aldosterone was greater than that of cortisol and corticosterone. The data obtained were not sufficient to give a relialle estimate of volumes of distribution. Also, the low specific activity of aldosterone then available made it necessary to administer 2 jug of hormone. This amount represents about 25 per cent of total body pool of hormone. Peterson reported a corresponding half-life of 0.5 to 0.8 hour in normal subjects after injection of tritiated d,l-aldosterone (2). Again in this study large quantities of the hormone were injected. Also it is not known whether the optical isomers of aldosterone are metabolized in an identical manner. The natural hormone is in the d form exclusively.

THE DISAPPEARANCE OF 7-H3-d-ALDOSTERONE IN THE PLASMA OF NORMAL SUBJECTS*