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An unexplained anomaly of "primaquine-sensitive" erythrocytes is their ability to resist hemolysis in vitro, even when exposed to concentrations of primaquine that are greatly in excess of pharmacologic levels. Beutler, Dern and Alving (1) have studied in vitro hem-iolysis of primaquinesensitive red cells in detail and demonstrated that it occurs between 1.5 and 4 x 10-3 M primaquine (0.6 to 2.0 mg per ml) when measured in a test system containing saline buffered at pH 7.0. They were unable to demonstrate any difference between normal and abnormal cells with respect to the drug concentration required to produce in vitro hemolysis. In vitro studies on normal cells, reported in an accompanying paper (2) generally demonstrated no hemolysis with concentrations of less than 5 x 10-3 M primaquine; these observations were made on whole defibrinated blood, and when compared with Beutler's studies of red cells suspended in buffered saline, it appears that serum proteins inhibited hemolysis of red cells exposed to concentrations of primaquine less than 5 x 10-3 M. In comparing in vitro observations on hemolysis produced by primaquine, with the in vivo effects of the drug, Beutler and colleagues have (1) suggested that the drug, or one of its metabolic by-products, damages the sensitive erythrocytes, thereby making them susceptible to removal by in vitro mechanisms but not to in vitro hemolysis. Brodie and Udenfriend (3), who studied the hemolytic effect of primaquine, suggested that a

EFFECTS OF PRIMAQUINE ON THE RED BLOOD CELL MEMBRANE. II. K+ PERMEABILITY IN GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENT ERYTHROCYTES*