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Previous studies from this laboratory (1) have cited a time-dose-cytotoxic relationship and a high dialysance 1 as important theoretical criteria for the selection of dialyzable poisons. Small molecular size, high solubility, clinical correlation with blood level and a primary distribution in the fluid phase of the body would suggest ethanol and methanol as ideal dialyzable toxins. Because of the time lag between ingestion of methanol and production of its lethal metabolites such as formic acid, early dialysis would seem critical in cases of methanol poisoning. Since each metabolite of methanol is more toxic, removal of the parent compound offers a unique leverage and constitutes preventive medicine as well as specific therapy.

THE DIALYSANCE OF ETHANOL AND METHANOL: A PROPOSED METHOD FOR THE TREATMENT OF MASSIVE INTOXICATION BY ETHYL OR METHYL ALCOHOL*