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Evidence for the existence in human plasma of a protein with high affinity for the binding of corticosteroids, which we have named transcortin, has been recently published from several laboratories (1-5). Even though the concentration of transcortin is considerably lower than that of albumin, the former binds cortisol approximately 6,000 times as strongly as does the latter (5). Therefore, under physiological conditions most of the plasma cortisol has been shown to be bound to transcortin. Transcortin appears to be saturated at plasma levels of cortisol of approximately 30 to 40 ug. per cent (4-5). Some of the characteristics of the corticosteroid-binding protein have been described by Daughaday (2, 6), Bush (3), Upton and Bondy (4) and ourselves (5). In a previous paper we reported a method for measuring the binding capacity of transcortin in plasma and showed it to be increased in the plasma of pregnant women (5). Since the concentration of transcortin may play an important role in the metabolism and biological effects of cortisol, it appeared worthwhile to ascertain the transcortin capacity in several clinical states. Data are presented in this paper on the transcortin binding capacity in the plasma of newborn infants and their mothers; in normal children of various ages; in patients with cirrhosis of the liver; in patients with miscellaneous diseases; and following the administration of estrogenic substances.

TRANSCORTIN: A CORTICOSTEROID-BINDING PROTEIN OF PLASMA. II. LEVELS IN VARIOUS CONDITIONS AND THE EFFECTS OF ESTROGENS *