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The advent of the use of hypothermia as an adjunct to surgery has revived interest in the effect of alterations of local temperature on tissue metabolism. In the early part of this century, several investigators (1, 2) performed in v4tro studies and found that increasing the temperature of muscle slices raised their oxygen consumption, while an opposite effect was produced by decreasing the temperature. The Q10 of this relationship was generally found to be slightly above the value of two (2). However, one limitation of the work was that the absolute oxygen consumption was closely dependent upon the composition of the bath in which the tissue was suspended. In more recent years a number of workers (3-5) have noted an increase in local circulation with exposure of a limb to high external temperatures and a decrease with cooling of the tissues. From such evidence it has been concluded that the alterations in blood flow produced by local heat and cold are due both to the direct action of these agents on the blood vessels and to changes in the metabolic needs of the tissues being supplied. However, it is apparent that data on the circulation alone are not sufficient for the determination of tissue oxygen utilization, and that for this purpose, the simultaneous measurement of the quantity of oxygen removed from the blood as it passes through the structures under study is likewise essential. Studies on the effect of hypothermia on the whole organism have also contributed to the elucidation of the problem. In the rat (6) and in the dog (7, 8) this state is associated initially with a

the journal of clinical investigation/the journal of clinical investigation

RELATIONSHIP BETWEEN A RANGE OF TISSUE TEMPERATURE AND LOCAL OXYGEN UPTAKE IN THE HUMAN FOREARM. III. CHANGES OBSERVED AFTER ANAEROBIC WORK, IN THE POSTEXERCISE PERIOD*†