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Methods employing radioactively tagged red cells have been widely adopted for measurement of blood volume. However, in comparison with the work which has been done with the dye (1-5) and carbon monoxide (6) methods, little attention has been given to the establishment of mean values for men and women or to study of the variance encountered among healthy subjects. Most clinical investigators have collected their own control data, based often on study of relatively few or not entirely healthy subjects (7-13). A rather large scatter of data around mean prediction values has been found by all workers, regardless of methods employed, when values for whole blood volume (Vwb), red cell volume (Vrbc) and plasma volume (Vpl) are related to body weight, height, or combinations of these measures (1-5, 13, 14). Some of this variation presumably results from differences in body composition, since blood volume correlates both with body density (5, 15) and with lean body mass (16, 17). However, it has not been shown that predictions based on total body mass are less accurate than those based on lean body mass, which requires a separate measurement (15, 16). Consideration of fat thickness and girth measurement, in addition to height and weight, was found by

the journal of clinical investigation/the journal of clinical investigation

RED CELL, PLASMA AND BLOOD VOLUME IN HEALTHY MEN MEASURED BY RADIOCHROMIUM (Cr51) CELL TAGGING AND HEMATOCRIT: INFLUENCE OF AGE, SOMATOTYPE AND HABITS OF PHYSICAL ACTIVITY ON THE VARIANCE AFTER REGRESSION OF VOLUMES TO HEIGHT AND WEIGHT COMBINED*