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This study was undertaken to ascertain whether different normal and abnormal hemoglobin components exhibit different rates of Fe59 incorporation in human subjects and in experimental animals. The hemoglobin of normal man contains minor components, hemoglobins A2 and A3, in addition to the principal component, hemoglobin A1. Patients with hereditary hemoglobin abnormalities have relatively large amounts of abnormal hemoglobins; electrophoretic analysis of the hemoglobin of many experimental animals reveals a

STUDIES OF THE INCORPORATION OF Fe59 INTO NORMAL AND ABNORMAL HEMOGLOBINS*