English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The adrenal cortical hormones have been thought to play a role in the pathogenesis of hypertension for the following reasons: 1) Hypertension is a characteristic finding in Cushing's disease; 2) large doses of desoxycorticosterone (DCA) and salt administered to Addisonian patients produce hypertension (1); 3) hypertensive patients who developed Addison's disease had blood pressure falls to normal limits which were restored to previous levels with DCA(2) ; and 4) 80 per cent of the patients with severe hypertension have had significant improvement for three to seven years following 90 to 100 per cent adrenalectomy and limited sympathectomy (3). Moreover, animal experiments (4, 5) have shown that hypertension following renal artery occlusion cannot be produced in the absence of adrenal cortical steroids. Despite these observations, altered adrenal function in hypertension has not been clearly demonstrated. While mean levels of cortical steroids in blood and urine (6-9) are not elevated in hypertensive patients, disturbances in salt and water metabolism observed in early hypertension prior to the development of renal damage by Green, Johnson, Bridges and Lehmann (10) and BraunMenendez (11) indirectly support the idea that the pattern of adrenal corticoids is altered. Brady (12) found that slices of canine adrenal tissue produce large quantities of steroids when incubated in vitro in autologous plasma and proposed the measurement of steroid formation in vitro as a direct assessment of the functional ca-

Steroid Formation by Adrenal Tissue from Hypertensives1