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Recent studies have indicated that the unesterified fatty acids in plasma (UFA) may represent a major form in which fat is transported to tissues for utilization as a source of energy. The evidence indicating the metabolic importance of UFA includes a close correlation between plasma UFA concentration and nutritional state (1, 2), direct evidence of removal of UFAby the heart and liver in fasting humans (2, 3), and the early participation of UFA in chylomicron metabolism (4). These studies have indicated that plasma UFA turnover must occur at a rapid rate. This fact has been established in recent studies on dogs (4-6), humans (7, 8), rabbits (9), and rats (10). The purpose of this paper is to describe the measurement of the rates of plasma turnover and oxidation of albumin-bound C"4-labeled unesterified fatty acids in normal human subjects. A tentative scheme for UFA metabolism in man is also presented.

The Metabolism of Albumin Bound C14-Labeled Unesterified Fatty Acids in Normal Human Subjects