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The effects of high spinal anesthesia on the general (1, 2), hepatic (3), and coronary (4) hemodynamics have been previously reported by our group. Because hypotension produced by high spinal anesthesia may be a potential hazard to the circulatory sufficiency of the brain, it was considered important to study the effects of high spinal anesthesia on the cerebral circulation and metabolism. Studies by others have been concerned with the effects of differential spinal block on the cerebral circulation of hypertensive individuals (5) and the effect of hypotensive drugs on the cerebral circulation of aged persons (6) and hypertensives (7). The majority of patients in this study are normotensive, but the effects of high spinal anesthesia on a small group of hypertensives is included. The anesthetic level is higher and the amount of spinal anesthetic agent employed is larger than in studies reported by others, simulating the dosage used in producing surgical high spinal anesthesia, although surgical procedures were not undertaken in these subjects.

EFFECTS OF HIGH SPINAL ANESTHESIA ON CEREBRAL CIRCULATION AND METABOLISM IN MAN12