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Thyroid hormone has long been thought to exert its primary effect in the peripheral tissues. Recent studies have indicated, however, that thyroxine may be converted to other products in these tissues before becoming metabolically active (1-4). Whether or not a subsequent alteration is necessary, it seems probable that the thyroxine must first be fixed in some form of physicochemical union, either on the surface of, or inside the cell, before it can exert its characteristic effect on the metabolism of the tissue. Probably the most complete study of this sort has been carried out by Stadie on the binding in vitro of insulin to various rat tissues, particularly diaphragm (5, 6). With respect to thyroxine and triiodothyronine, Hamolsky and Crispell and coworkers have studied the effect of plasma on the binding of these hormones to red blood cells in vitro (7-9) and Gross has reported similar studies relative to liver slices (10). Since one significant site of thyroid hormone localization seems to be the muscle mass of the body (11), it should be of interest to study the binding in vitro of thyroxine to a specific tissue such as rat diaphragm. In fact, one such study has been reported by Hamolsky and Freedberg (12) who investigated differences in the rate of uptake by rat diaphragm of thyroid hormone from the plasma of normals and thyrotoxic patients. The purpose of this report is to present information on the nature of the binding phenomenon exhibited by rat diaphrgam in vitro, relative to thyroxine and triiodothyronine labeled with I"'.

THE CONCENTRATION AND BINDING OF THYROXINE AND TRIIODOTHYRONINE BY RAT DIAPHRAGM 1