English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Although the hemodynamic events attending low-output congestive heart failure have been well defined, the biochemical changes in the myocardium responsible for these events and the response to cardiac glycosides remain largely unknown. Evidence to date suggests that in the failing heart there is normal substrate oxidation but an impairment of energy utilization (1). Recent data would indicate an altered state of the myocardial protein-complex, actomyosin (2), but whether this is the primary event in the evolution of congestive failure remains to be demonstrated. Post-mortem tissue analyses for cation content of human heart muscle in failure have shown a lowered content of potassium (3, 4). Moreover, after digitalis, in therapeutic (5) and toxic doses (5, 6), the potassium content diminishes, although some disagreement over the former exists. That these changes may have functional significance is suggested by the work of Hajdu (7), who, from data obtained with a frog heart-muscle preparation, has inferred that the positive inotropism of digitalis is effected by the reduction in internal ionic content produced by the transfer of potassium from the cell. The pronounced effect of digitalis on the mechanical efficiency of the failing myocardium (8, 9) suggests that this drug might provide data re-

MYOCARDIAL TRANSFER OF SODIUM AND POTASSIUM: EFFECT OF ACETYL STROPHANTHIDIN IN NORMAL DOGS 12