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Radioactive mercury, administered intravenously in the form of an organic mercurial diuretic, Meralluride (Mercuhydrin@), leaves the plasma of man as a multiple exponential function of time. Threefoot, Ray, Burch, Cronvich, Milnor, Overman, and Gordon (1) demonstrated that no less than three major exponential rates are responsible for this regression of plasma mercury concentration. They postulated that the fastest rate represents mechanical mixing in the plasma compartment; that the intermediate rate represents rapid adsorptive, chemical and diffusion phenomena, including migration into tissues; and that the slowest rate represents mainly renal excretion. Early in our work with mercurial diuretics labelled with radioactive mercury, we observed that Chlormerodrin (Neohydrin@), administered in a single intravenous dose, disappears from the plasma of the dog in a similar fashion. Indeed the time constants of the individual exponentials in the dog were comparable to those in man. Experiments described below were undertaken to test the postulates of Threefoot and his co-workers (1) concerning the nature of the processes involved in the clearing of mercury from the plasma and have served to verify and amplify their conclusions. Additional experiments describe the extraction, excretion and accumulation of mercury by the kidneys and relate these processes to the development of diuresis and to the disappearance of mercury from the plasma.

the journal of clinical investigation/the journal of clinical investigation

PLASMA REGRESSION, DISTRIBUTION AND EXCRETION OF RADIOMERCURY IN RELATION TO DIURESIS FOLLOWING THE INTRAVENOUS ADMINISTRATION OF Hg203 LABELLED CHLORMERODRIN TO THE DOG 1