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The purpose of this study is to contribute to an understanding of the mechanism of production of various types of hyperlipemia by comparing the plasma phospholipid turnover time in normal individuals and in patients with elevated plasma lipids. The rate of incorporation of a single tracer dose of P32 labeled carrier-free inorganic phosphate into the plasma phospholipids has been measured and a mathematical procedure described by Zilversmit, Entenman, and Fishler (1) has been used for the calculation of the turnover time of the sum of phospholipid phosphorus contained in the plasma and liver. Results obtained in six normal individuals, in five patients with the nephrotic syndrome and in three patients with hyperlipemia due, respectively, to hypothyroidism, biliary cirrhosis and essential familial xanthomatosis will be presented.

the journal of clinical investigation/the journal of clinical investigation

ESTIMATION OF THE PHOSPHOLIPID PHOSPHORUS TURNOVER TIME IN MAN: STUDIES IN NORMAL INDIVIDUALS, IN PATIENTS WITH THE NEPHROTIC SYNDROME AND IN OTHER TYPES OF HYPERLIPEMIA 1