English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The effects of heparin on the electrophoretic pattern of serum have recently been studied in this Laboratory. It had been found that in normal, strictly fasting individuals an intravenous injection of heparin caused no changes in the patterns obtained either by moving boundary electrophoresis or by paper electrophoresis (1-4). On the other hand, in alimentary hyperlipemia and idiopathic hyperlipemia electrophoretic changes were observed. In the patterns obtained by moving boundary electrophoresis the changes consisted of a decrease in the beta-1 globulins to a subnormal value and the appearance of a new component ahead of albumin (1, 2). On the basis of this observation it had been assumed that the pre-albumin component consisted of beta lipoproteins. However, subsequent studies by paper electrophoresis revealed that after an injection of heparin not only the beta lipoproteins but also the alpha lipoproteins showed an acceleration of their electrophoretic migration: The beta lipoprotein lipid band moved with the speed of either alpha-2 globulin, alpha-1 globulin, or intermediary between alpha-1 globulin and albumin and the alpha lipoprotein lipid band moved faster than albumin (3, 4). Because the findings by paper electrophoresis indicated that the pre-albumin component consisted of the alpha lipoproteins and not of the betalipoproteins, as we had originally assumed, it was thought worth while to study in greater detail the effects of heparin on the alpha and beta lipo-

the journal of clinical investigation/the journal of clinical investigation

EFFECTS OF HEPARIN ON THE LIPOPROTEINS IN HYPERLIPEMIA. AN ELECTROPHORETIC STUDY OF THE SERUM ALPHA AND BETA LIPOPROTEINS AFTER THEIR SEPARATION BY FRACTIONATION OF THE PLASMA PROTEINS OR ULTRACENTRIFUGAL FLOTATION 1