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The status of pregnancy profoundly affects the maternal metabolism. By means of isotopic tracers over-all changes in metabolic rates of specific substances can, with certain limitations, be studied. This investigation is concerned with the demonstration of water turnover rates during various stages of pregnancy and an effort is made to define their physiologic and pathologic variations. Based upon clinical evidence, appreciable variations in the state of hydration are expected as pregnancy progresses and even greater variations may be anticipated under certain pathologic conditions. For this reason the water economy of the pregnant woman is of considerable interest to the clinician. Numerous investigations have been carried out to determine changes in specific fluid

THE TOTAL BODY WATER AND THE WATER TURNOVER IN PREGNANCY STUDIED WITH DEUTERIUM OXIDE AS ISOTOPIC TRACER 1