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To study the clinical effects of experimentally induced pain, as initiated by Kellgren and Lewis, hypertonic saline was injected into selected areas of muscle and about certain tendons and ligaments in a number of individuals (1-3). The resulting subjective sensations and the nature and extent of the objective changes were noted, then tabulated and compared by coworkers not participating in the experiments. This report presents our observations and deductions.

OBSERVATIONS ON PAIN PRODUCED BY INJECTION OF HYPERTONIC SALINE INTO MUSCLES AND OTHER SUPPORTIVE TISSUES