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patients. One of them (M. Y.) presented anxiety manifestations before the studies were started. These symptoms became accentuated after the Aminophylline was given. Additional pertinent clinical data are given in Table I. The studies were carried out with the patients in the supine position. Two who were too orthopneic to lie supine were tilted to 20 degrees during the entire study. Measurements of pulse rate, respiratory rate, and auscultatory blood pressure were taken during the course of each experiment. Mean blood pressures were calculated on the basis of the diastolic pressure plus one-third of the pulse pressure. A control cerebral blood flow determination was completed employing the nitrous oxide method (6). Nitrous oxide was administered and blood samples collected over a 20 minute period, instead of the usual 10, since equilibrium of nitrous oxide concentration was not always established at 10 minutes due to the decreased blood flow and low rate of arterial delivery of nitrous oxide to the brain. In the patients who exhibited

the journal of clinical investigation/the journal of clinical investigation

THE EFFECT OF THEOPHYLLINE WITH ETHYLENEDIAMINE (AMINOPHYLLINE) ON CEREBRAL HEMODYNAMICS IN THE PRESENCE OF CARDIAC FAILURE WITH AND WITHOUT CHEYNE-STOKES RESPIRATION 1