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It has been found that when normotensive or hypertensive subjects are tilted passively into an upright position estimated hepatic blood flow (EHBF) (2) decreases and calculated hepatic portal resistance (HPR) increases (3). These changes were assumed to be due to active splanchnic vasoconstriction, probably mediated over the splanchnic sympathetic nervous system. Direct evidence bearing on this assumption became available in some of the hypertensive patients undergoing splanchnic sympathectomy and subsequently studied by the same methods as before operation. Such studies are the basis of the present report.

the journal of clinical investigation/the journal of clinical investigation

THE EFFECT OF SPLANCHNIC SYMPATHECTOMY IN HYPERTENSIVE PATIENTS UPON ESTIMATED HEPATIC BLOOD FLOW IN THE UPRIGHT AS CONTRASTED WITH THE HORIZONTAL POSITION 1