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Thouglh the appearanice of streptomycini-resistant bacteria during the course of streptomycin therapy has been abundantly demonstrated (1), less attention has been paid to the ultimate fate of these resistant formiis. Our attention was drawn to this problem during an investigation of the development of streptomycin-resistant variants among the normally commllensal but potentially pathogenic flora of the body. Though streptomycin-resistant coliformii bacilli are almost uniformly absent from the stools of human beings who have not receive(d streptomycin. they frequently appear during the intramiuscular administration of streptomycin for certain types of tuberculosis (2) and during its oral a(Idmiinistration for various purposes. Our investigationis lhave shown that in mnany cases the normally "senisitive" coliformiis were replace(d during treatmenit by resistant strains of the same species. However, when streptomycin was discontinued, and in special instances, even before the (Irug was (lisconitinued, sensitive coliforms began to reappear an(d finally crow(le(l out the resistant variants altogetlher. It is the purpose of this paper to presenit the dlata dealing with this replacemiient of resistant by sensitive strains.

the journal of clinical investigation/the journal of clinical investigation

THE REPLACEMENT OF STREPTOMYCIN-RESISTANT COLIFORM BACTERIA IN THE STOOLS BY STREPTOMYCIN-SENSITIVE VARIANTS DURING AND FOLLOWING THE CESSATION OF STREPTOMYCIN THERAPY 12