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It has often been assumed that moderate degrees of hypoxia render the capillaries abnormally permeable to fluid and protein. During the course of work concerned with methods of insuring pilot survival at altitudes above 45,000 ft., it became desirable to know the degree and duration of anoxic anoxia that could be tolerated before permeability changes of the capillary bed occurred. The studies of Landis ( 1 ) have demonstrated that complete ischemic anoxia of 3 minutes' duration will cause temporary damage to the capillaries of the frog's mesentery and result in abnormal permeability to fluid and protein. Pochin (2) working with the rabbit's ear has found that complete occlusion of the circulation for 2 hours will lead to demonstrable edema following reestablishment of the circulation. He also showed that 16 to 18 hours of occlusion resulted in edema fluid containing approximately 5 grams per cent of protein. Calvin (3) has found that during the terminal stages of fatal asphyxia there is evidence of a marked loss of protein and of the proteinattached dye T 1824 from the capillary bed. These experiments involved very intense anoxia and on turning to work done under less severe conditions the results are seen to be less conclusive. Thus Calvin (3) and also Hopps and Lewis (4) found no change in the rate of filtration of plasma protein and of the dye T 1824 in the course of severe but non-fatal anoxia. On the other hand Maurer (5) and Warren and Drinker (6) have shown that, in the dog, the flow of cervical and lung lymph increases during severe but non-fatal anoxic anoxia. However

CAPILLARY PERMEABILITY IN RELATION TO ACUTE ANOXIA AND TO VENOUS OXYGEN SATURATION 1