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In a recent study (1), it was reported that the parenteral administration of histamine produced a sizable reduction of vital capacity in 8 of 9 actively asthmatic subjects, whereas it produced no significant change of vital capacity in 2 control groups of normal individuals and patients with hay fever. Furthermore, the effectiveness of histamine in producing a reduction in vital capacity varied in different asthmatic subjects and also in the same subject with the degree of asthma present at .the time the tests were done. The present communication reports the action of acetyl-beta-methyl choline chloride (mecholyl chloride) on the vital capacity in asthmatic subjects, in patients with hay fever, and in a group of normal individuals and presents a comparison of the effect of mecholyl chloride with that of histamine. These assays were carried out in the hope of further elucidating the underlying mechanisms in asthmatic attacks. In 1912, Barker and Sladen (2) noted the action of pilocarpine and atropine in bronchial asthma. Alexander and Paddock (3) induced "asthmatic-like" attacks in 10 of 20 patients with asthma by the subcutaneous injection of 3 mgm. pilocarpine. The latter workers observed that the systemic response to pilocarpine, as manifested by salivation, sweating, epiphora, flushing, and a sensation of warmth, was slightly greater in the asthmatic subjects than in the normal subjects. Starr, Elsom, Reisinger, and Richards (4) with the subcutaneous administration of 20 mgm. acetyl-beta-methyl choline inadvertently precipitated an "asthmatic-like" attack lasting 3 minutes in a young subject with a past history of asthma. Starr (5) also produced mild "asthmatic-like" attacks in asthmatic patients with acetyl-beta-methyl

the journal of clinical investigation/the journal of clinical investigation

COMPARATIVE ACTION OF ACETYL-BETA-METHYL CHOLINE AND HISTAMINE ON THE RESPIRATORY TRACT IN NORMALS, PATIENTS WITH HAY FEVER, AND SUBJECTS WITH BRONCHIAL ASTHMA 1