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The ability of antihistamine substances, sympathomimetic amines and other drugs to counteract histamine bronchoconstriction in animals has received widespread attention (1 to 10). Such tests have not been applied to normal human subjects because of failure to demonstrate significant amounts of bronchoconstriction after doses of histamine that may be safely administered. However, the occurrence of bronchoconstriction in many asthmatic patients following the administration of histamine has been confirmed (11). It was also discovered that this sensitivity to histamine varied from person to person and in the same individual with the severity of the asthmatic symptoms. Moreover, during any one period of study, repeated intramuscular or intravenous injections of identical quantities of histamine produced similar amounts of bronchoconstriction. Thus, the tracheobronchial reaction to histamine in a sensitive subject provides a means of assaying the effectiveness of various antihistamine preparations, as well as of other drugs, in counteracting this type of bronchoconstriction.

THE EFFECT OF ANTIHISTAMINE SUBSTANCES AND OTHER DRUGS ON HISTAMINE BRONCHOCONSTRICTION IN ASTHMATIC SUBJECTS 1