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Evidence has already been presented that prior administration of iodine to patients with hyperthyroidism does not prevent the action of thiourea (1). Some cases behaved as if the action of iodine actually supplemented that of thiourea, but the evidence for such an additive effect was inconclusive. On the other hand, various writers have maintained that preliminary treatment with iodine delays the action of thiouracil (and so, possibly, of thiourea), even if it does not entirely obviate it (2 to 11). From a practical as well as a theoretical viewpoint it is essential to decide which interpretation is correct. If the actions of the two agents are additive, or at least do not interfere with one another, they may well be given together. If, on the other hand, the prior or simultaneous administration of iodine delays the action of thiourea, it would be advisable to avoid combined treatment. The present study seeks to resolve this problem by a comparison of the effects in hyperthyroid patients of treatment with thiourea alone, and with both iodine and thiourea. Further observations on the treatment of hyperthyroidism with thiourea are included, particularly concerning the eventual need for thyroid medication to control hypothyroidism.

ADDITIVE EFFECTS OF IODINE AND THIOUREA IN THE TREATMENT OF HYPERTHYROIDISM 1