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That disturbances in consciousness, and consequently in behavior, are produced by anoxia is well known. The clinical picture is essentially that of delirium, a syndrome in which we have pointed out that the primary psychologic symptom is a reduction in the level of consciousness (1). With moderate or severe degree of anoxia the changes are grossly obvious. The evaluation of the harmful effects of mild degrees of anoxia, however, has proven extremely difficult due to the lack of accurate methods of measuring such effects. Such measurements are of obvious importance to aviation medicine and are of interest in studies of the earliest changes in delirium. So far, the most satisfactory methods have concerned changes in visual functions. Various performance and psychological tests have all proven relatively unsatisfactory due to the wide range of individual responses, doubtless influenced by motivation and emotional factors. In such studies statistical analyses of a large number of subjects indicate that significant degrees of impairment of performance begin around 12,000 feet (483.3 mm. Hg). Numerous investigators have reported the effects of anoxia, hypoglycemia, and various drugs on the electroencephalogram, but for the most part, these studies have been concerned with the more marked changes. The demonstration of a close relationship between changes in frequency distribution in the electroencephalogram and levels of consciousness (1) and the development of a quantitative method for analyzing electroencephalographic frequency spectra (2) offer a practical approach to the study of cortical function during mild to moderate degrees of anoxia. The

QUANTITATIVE ELECTROENCEPHALOGRAPHIC STUDIES OF ANOXIA IN HUMANS; COMPARISON WITH ACUTE ALCOHOLIC INTOXICATION AND HYPOGLYCEMIA 1