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Numerous studies of the serum or plasma proteins in malaria have shown that there is a depression of albumin and a relative rise of globulins following paroxysms. Two workers (1), from a review of the earlier literature and from experimental studies with monkey malaria, concluded that, while the changes were not specific for malaria, the amount of change generally correlated with the intensity of an attack. In the interval between relapses, the serum total protein and albumin:globulin values tended to return toward normal, an improvement that was accelerated by treatment. Later observations on human subjects (2 to 4) have also been in accord with these findings. Although it has been suggested (5) that the increase in the serum fraction precipitable by 13.5 per cent sodium sulfate might be sufficiently characteristic of the disease to be the basis of a diagnostic test for malaria, the subsequent use of this test (6) indicated that similar increases would also be encountered in a variety of other diseases. All previous studies have been made with some type of salt fractionation. The purpose of the present study was to supplement these earlier observations by electrophoretic analyses, and to ascertain whether or not any test based upon changes in the plasma protein pattern might be of diagnostic use in the group of patients with relapsing malaria.

ELECTROPHORETIC CHANGES IN THE PLASMA PROTEIN PATTERNS OF PATIENTS WITH RELAPSING MALARIA 1