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Certain authors have postulated (1 to 4) that the intravenous administration of crystalline trypsin into animals causes a type of shock that is similar to that produced in anaphylaxis or after peptone injection. The following argument is developed by these authors in order to support this hypothesis. Histamine is released when smooth muscle is perfused with trypsin solution (2); and a similar production of histamine occurs in anaphylactic shock (5, 6). In trypsin shock, a prolonged clotting time of the blood is observed, which these authors attribute to the presence of heparin (7). In peptone (8) and in anaphylactic shock, delayed coagulation also occurs due to heparin, which has actually been isolated (9) from the blood of dogs in anaphylactic shock. Since trypsin possesses the power to coagulate blood by converting prothrombin to thrombin even in the absence of ionic calcium (10), it seemed interesting to determine whether this production of thrombin is a factor in the shockproducing activity of trypsin. Accordingly, the effects of the injection of trypsin and thrombin on the blood pressure and the blood coagulation mechanism were compared in experimental animals.

THE NATURE OF THE MECHANISM OF THE SHOCK PRODUCED BY THE INJECTION OF TRYPSIN AND THROMBIN