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The results of simultaneous measurements of the volume of distribution of carbon monoxide and that of Evans blue dye (T1824), in normal man and in normal and splenectomized dogs, have been reported elsewhere (1). It was found that, although measurements of the blood volume by the 2 methods were frequently numerically equivalent, occasionally either carbon monoxide or dye might measure a larger space. On the average, the results with the 2 methods were very nearly the same, in spite of these occasional variations. In the present study, the same method of investigation has been applied to pathological subjects. Studies, both of patients and of dogs, have been carried out. The human subjects consisted of hospitalized patients with various disorders, affecting either the state of the vascular system or the chemical constitution of the body fluids. The dogs were first studied in their normal state, and again after being subjected to various procedures likely to affect the vascular system. These experimental procedures included traumatic shock, salt and water depletion, hemorrhage, adrenal insufficiency, and the injection of epinephrine. The extent to which the normal relationship existing between the results obtained by the 2 methods persisted in pathological states could thus be determined. Furthermore, in the dog experiments, the reliability of these 2 methods as relative measures of blood volume could to some extent be determined. The results could also be com-

the journal of clinical investigation/the journal of clinical investigation

SIMULTANEOUS MEASUREMENTS OF THE BLOOD VOLUME IN MAN AND DOG BY MEANS OF EVANS BLUE DYE, T1824, AND BY MEANS OF CARBON MONOXIDE. II. UNDER ABNORMAL CONDITIONS, INCLUDING SECONDARY SHOCK 1