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The present report is concerned primarily with the use of concentrated human albumin solutions, produced from pooled normal human plasma by the method of Cohn and co-workers, (1), in the treatment of shock in man.This work represents a part of a more general study (3) of the circulation in human cases of shock, which has been in progress at Bellevue Hospital, New York City, during the past two years. In addition, the -therapeutic effects of concentrated human albumin will be compared with the effects of whole blood, and of rapid intravenous saline infusion. Before presenting the results of this investigation, it may be well to define briefly two separate aspects of shock therapy, since the differentiation of these provides the basis of our comparison of the three types of treatment used. For successful treatment of clinical shock, two things are essential; first, to restore the failing

the journal of clinical investigation/the journal of clinical investigation

CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. VIII. CLINICAL USE OF CONCENTRATED HUMAN SERUM ALBUMIN IN SHOCK, AND COMPARISON WITH WHOLE BLOOD AND WITH RAPID SALINE INFUSION 12