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The importance of the standardization of new products of therapeutic value need hardly be stressed in this place. In the fractionation of plasma proteins on a large scale, it is necessary to have means of determining the uniformity of the products for the purpose of insuring predictable clinical responses. In the case of the products from human plasma, it seemed most appropriate to employ not only clinical but also physical chemical methods of control-procedures which had been of value in the development of these products.

the journal of clinical investigation/the journal of clinical investigation

CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. I. THE CHARACTERIZATION OF THE PROTEIN FRACTIONS OF HUMAN PLASMA 12