English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

This report concerns the systemic and renal circulatory changes in normal man during the action of adrenin, ephedrine, and paredrinol. Special attention has been paid to the interrelationship and integration of the many factors involved in the production of the over-all response. Although these three substances are similar chemically and have long been known (1) as vasopressor drugs, their sites and modes of action appear to vary. The observations presented here throw light upon the circulatory mechanisms involved in the pressor response. The subjects were male convalescent patients on the Third (New York University) Medical Division of Bellevue Hospital, who were examined, for the most part, under basal conditions. Adrenin was administered subcutaneously and intramuscularly in 0.5 to 1.5 mgm. doses, ephedrine was given intramuscularly in 50 to 75 mgm. doses, and paredrinol was injected intramuscularly in 20 to 30 mgm. doses, after control values had been obtained. Cardiac output was determined by a modification of Starr's ballistocardiograph (2), using the wave area formula advocated by Starr (3). The instrument was calibrated after each study by the method recommended by Starr (4). All figures for stroke volume and cardiac output have been increased by 18.5 per cent because Cournand et al. (2) have shown the ballistocardiographic output to average 18.5 per cent lower than the value obtained by the direct Fick method in man. Arterial pressure was measured directly in the femoral artery with a Hamilton optical manometer (5) and mean pressure was obtained by planimetric measurement of the area under the pressure pulse curve. The total peripheral vascular resistance was calculated in absolute units by

SYSTEMIC AND RENAL CIRCULATORY CHANGES FOLLOWING THE ADMINISTRATION OF ADRENIN, EPHEDRINE, AND PAREDRINOL TO NORMAL MAN