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upper respiratory infections. Since, however, the total number of rheumatic recurrences was small, it seemed possible that the relationship of the streptococcal pharyngitis to the reactivation of the rheumatic process might have been accidental. To rule out this possibility, it was essential to study the effect of preventing streptococcal upper respiratory infections in rheumatic subjects by some

the journal of clinical investigation/the journal of clinical investigation

THE PREVENTION OF STREPTOCOCCAL UPPER RESPIRATORY INFECTIONS AND RHEUMATIC RECURRENCES IN RHEUMATIC CHILDREN BY THE PROPHYLACTIC USE OF SULFANILAMIDE 1