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Recent advances in the study of human nutrition indicate that a clinical deficiency of vitamins or other food factors may occur not only because of an inadequate intake or because of faults in storage or in utilization within the body, but also because of faulty absorption from the digestive tract. Consequently an accurate, direct and quantitative method of estimating the absorption of such substances in the human, under controlled conditions, is urgently needed. Various technics, including some developed in this clinic since 1934, have been used as a basis for the method which we will now describe and which seems to have certain advantages over those previously employed. At the same time, to illustrate the practical value of the method, we will present certain observations on its application to the absorption of ascorbic acid from the duodenojejunal region of normal subjects. The results have been of such a nature as to suggest that the method is trustworthy and applicable to the testing of other substances in health and in disease.

INTUBATION STUDIES OF THE HUMAN SMALL INTESTINE. XXII. AN IMPROVED TECHNIC FOR THE STUDY OF ABSORPTION; ITS APPLICATION TO ASCORBIC ACID