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In previous articles the effects of sodium evipal 2 or sodiumi pentothal 3 anesthesia uponl the respiratory control mechanisms were described. Both anesthetics depress the central chemical mechanism of breathing (carbon dioxide control) much more rapidly than they depress the peripheral reflex chemical mechanisms (carotid and aortic chemoreflexes) (1), and the vagopulmonary proprioceptive reflexes (Hering-Breuer) (2). These observations are in agreement with the earlier findings of Henderson (3), Marshall and Rosenfeld (4), and Comroe and Schmidt (5) for anesthetic states produced by other barbiturates. The experiments reported here were planned so that the relative r6les played by carbon dioxide and by oxygen, in the control and maintenance of breathing at differentt depths of evipal and pentothal anesthesia, could be more fully evaluated. Accordingly, the respiratory responses to a coInstant increase in the carbon dioxide content, and to a constant decrease in the oxygen contenit of the inspired air were recorded at three levels of anesthesia. This provided a gross measure of the ability of an animal (dog) to react to fairlv constant chemical stimulation of the respiration. The stimulating agents chosen exhibit certain differences in their sites of action. In addition, the effects of increasing the oxygen tension of arterial blood above that present when the animals breathed room air were studied in order to determine roughly the degree of anoxic chemoreflex activity at different anesthesia levels when the animals were breathing air.

the journal of clinical investigation/the journal of clinical investigation

EFFECTS OF BARBITURATE ANESTHESIA (EVIPAL AND PENTOTHAL SODIUM) UPON THE INTEGRATION OF RESPIRATORY CONTROL MECHANISMS. A STUDY DIRECTED TOWARD IMPROVEMENT OF METHODS FOR THE PRECLINICAL EVALUATION OF ANESTHETIC AGENTS