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Wehave recently had available a solution containing a high concentration of sulfapyridine in 50 per cent glucose which can be conveniently administered orally, subcutaneously and intravenously (1). This offered an opportunity to study -the effect of the route of administration of a drug containing sulfapyridine on the blood level and urinary excretion and to compare it with other derivatives of sulfanilamide. The results of the biochemical studies are presented in this paper. The bacteriological and clinical results are presented elsewhere (1, 2).

the journal of clinical investigation/the journal of clinical investigation

A COMPARATIVE STUDY OF THE BLOOD CONCENTRATIONS AND URINARY EXCRETION OF SULFAPYRIDINE AND SULFANILAMIDE AFTER SINGLE DOSES OF SULFAPYRIDINE AND RELATED COMPOUNDS ADMINISTERED BY VARIOUS ROUTES