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This paper reports a comparison between normal subjects and patients with diabetes insipidus of some blood and urine responses to the ingestion of water and of hypertonic salt solution, both with and without pitressin. One aspect of this work, the responses of normal and diabetes insipidus subjects to water without pitressin, has already been reported (1). Since the earlier work showed failure of the human diabetes insipidus subject to respond to water ingestion with an acute increase in urine volume, one purpose of the present work is to determine whether such subjects show a corresponding failure, as compared with the normal, of responses as regards salt. Ability to conserve salt when on a low salt intake has also been studied. There has further been a comparison of the acute responses to salt ingestion while on an unrestricted and on a low salt intake.

RESPONSES OF NORMAL SUBJECTS AND OF PATIENTS WITH DIABETES INSIPIDUS TO WATER AND SALT INGESTION 1