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The clinical differentiation of obstructive jaundice from that due to derangements of the liver is frequently impossible despite careful history taking and physical examination and the employment of many types of diagnostic procedures. Patients with grave hepatitis are often subjected to the added hazard of an anesthetic and laparotomy to rule out possible biliary tract obstruction, while conversely, exploration may be delayed perilously long in cases of obstruction in the hope that the jaundice will subside spontaneously. In a previous preliminary report (1) the author has described a simple test by which disturbances in the hepatic parenchyma may be recognized by noting the capacity of the serum in these cases to flocculate a colloidal suspension of a cephalincholesterol complex. This test can be performed in any adequately equipped routine medical laboratory, since the reagents are few and relatively stable and no costly apparatus is required.

SEROLOGICAL DIFFERENTIATION OF OBSTRUCTIVE FROM HEPATOGENOUS JAUNDICE BY FLOCCULATION OF CEPHALIN-CHOLESTEROL EMULSIONS