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Many pressor substances, including hormones, drugs, and variously prepared extracts of kidney tissue, have been studied intensively to determine their effects on blood pressure and their possible role in the pathogenesis of human hypertension. Many of these experiments were performed on anesthetized animals and observations usually dealt merely with changes of systemic blood pressure. According to recent studies, however, one of the remarkable features of human hypertension is the association of abnormally high arterial pressure with normal peripheral blood flow. When vasoconstrictor tone in the extremities is diminished by warming the body, blood flow in the forearm increases equally in hypertensive and normal subjects (1, 2). It seemed highly desirable therefore to determine whether the action of any of the known pressor substances simulated human hypertension to the extent of producing, in an experimental animal, a rise of blood pressure without reducing peripheral blood flow simultaneously. In order to study the action of pressor substances on peripheral blood vessels it was found necessary to develop a method which (1) did not require anesthesia, (2) excluded variations arising from spontaneous changes in vasoconstrictor tone of nervous origin, (3) avoided trauma of the vessels studied, and (4) permitted intravenous injection at constant rates over long periods in order to reveal minor changes. The usual oscillometric technique was therefore modified to permit photographic recording of systolic blood pressure and pulse amplitude in the central artery of the rabbit's ear while vasoconstrictor tone of nervous origin was abolished by warming

THE EFFECTS OF PRESSOR DRUGS AND OF SALINE KIDNEY EXTRACTS ON BLOOD PRESSURE AND SKIN TEMPERATURE 1