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Man, as is well known, is one of the few species whose blood cells are permeable to glucose. The permeability rate of human blood cells for glucose has been the subject of many investigations attempting to define the significant factors of this phenomenon. Ege (1) was the first to investigate the importance of the concentration of the glucose. With a low glucose concentration there rapidly occurred a balance between'the glucose in the extracellular fluid and the watery phase of the blood cells; with a higher degree of concentration, the blood cells gradually became swollen, with a much slower inward diffusion rate (a contributing factor here, however, was a probable simultaneous outward flow of potassium from the blood cells). These conditions were more thoroughly examined by Bjering (2) who likewise found the rate of diffusion slower when the concentration of glucose was raised. He noted further that the diffusion rate for glucose gradually diminished to a degree greater than might be expected from Fick's law 1 as more glucose entered the blood cells. 'There is much to suggest that it is a question of a tightening of the pores of the blood cell membranes in the presence of glucose molecules, as a similar lowering of the diffusion rate has been observed when collodium membranes are employed. Bjering showed too that the inward flow of the glucose could be brought to a complete standstill by the addition of cyanide of mercury to the sus-

VARIATIONS IN THE PERMEABILITY OF THE RED BLOOD CELLS IN MAN, WITH PARTICULAR REFERENCE TO THE CONDITIONS OBTAINING IN PERNICIOUS ANEMIA