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The observations recorded in the preceding section form a fairly satisfactory background for further investigations. In these studies, which may be regarded as controls, it was found that the titer of the antistreptolysin of the serum varied within narrow limits from one normal person to another, 75 per cent giving titers between 25 and 50 units. It was, in addition, noted that the antistreptolysin titer remained fairly constant in the same individual from month to month, provided a hemolytic streptococcal infection did not supervene. The antistreptolysin in the serum from patients affected by a variety of chronic diseases behaved in much the same manner as in normal persons, for only 14 out of 84 patients gave titers above 100 units, and none gave titers of 200 units or over. The serum from a limited number of acute infections, caused by agents other than hemolytic streptococci, were also examined, often at frequent intervals during the course of the disease. Though there was a tendency for the antistreptolysin content to remain within normal limits, both during the acute stage and during convalescence, 43 of 66 cases giving titers between 25 and 50 units, it was noted that the variations from person to person were a little more frequent than they were in the normal individual or in the chronically diseased. Titers slightly above those of the normal adult were occasionally encountered, 22.7 per cent of 66 cases giving titers above 100 units and 2 patients giving titers of 250 units. With this information in hand it was possible to consider the problem presented by patients with infections caused by hemolytic streptococci for we may conclude, as have others, that the antistreptolysin titer of the serum

the journal of clinical investigation/the journal of clinical investigation

STUDIES OF THE VARIATIONS IN THE ANTISTREPTOLYSIN TITER OF THE BLOOD SERUM FROM PATIENTS WITH HEMORRHAGIC NEPHRITIS. II. OBSERVATIONS ON PATIENTS SUFFERING FROM STREPTOCOCCAL INFECTIONS, RHEUMATIC FEVER AND ACUTE AND CHRONIC HEMORRHAGIC NEPHRITIS